Author

C. Coblentz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

J. E. Maxson· 3 shared T. P. Braun· 3 shared Z. Schonrock· 3 shared A. Foley· 2 shared B. J. Druker· 2 shared B. M. Smith· 2 shared R. Callahan· 2 shared S. A. Carratt· 2 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersCancer Biology

J. E. Maxson

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3 papers

Recent·Most cited

Mutant SETBP1 enhances NRAS-driven MAPK pathway activation to promote aggressive leukemia

S. A. Carratt, T. P. Braun, C. Coblentz, Z. Schonrock, R. Callahan, B. M. Smith, L. Maloney, A. Foley, J. E. Maxson

This study shows that SETBP1 mutations enhance NRAS-driven MAPK signaling in leukemia, making cells sensitive to MEK inhibitor trametinib.

bioRxiv · Feb 1, 2021Cancer Biology

ASXL1 Directs Neutrophilic Differentiation via Modulation of MYC and RNA Polymerase II.

T. P. Braun, J. Estabrook, L. Darmusey, D. J. Coleman, Z. Schonrock, B. M. Smith, T. Enright, A. Taherinasab, C. Coblentz, W. Yashar, R. Callahan, H. Mohammed, B. J. Druker, T. Lusardi, J. E. Maxson

This study identifies ASXL1's role in neutrophil differentiation by modulating MYC and RNA Polymerase II, showing its impact on granulocyte maturation and myeloid malignancies.

bioRxiv · Sep 14, 2020 · PreprintCancer Biology

Myeloid Lineage Enhancers Drive Oncogene Synergy in CEBPA/CSF3R Mutant Acute Myeloid Leukemia

T. P. Braun, M. Okhovat, C. Coblentz, S. A. Carratt, A. Foley, Z. Schonrock, K. Nevonen, B. Davis, B. Garcia, D. LaTocha, B. R. Weeder, M. R. Grzadkowski, J. C. Estabrook, H. G. Manning, K. Watanabe-Smith, , J. E. Maxson

The paper identifies mutation synergy between CSF3R and CEBPA in AML, showing their interaction at myeloid lineage enhancers and the requirement of CEBPA mutations as an initial event.

bioRxiv · May 15, 2019Cancer Biology