M. P. Andreas

The biosynthesis of the odorant 2-methylisoborneol is compartmentalized inside a protein shell

The paper redefines the function of EshA as a protein shell encapsulating 2-MIB synthase, showing it is a cargo-loaded nanocompartment for secondary metabolite biosynthesis.

A two-component quasi-icosahedral protein nanocompartment with variable shell composition and irregular tiling

The paper characterizes a two-component encapsulin from Streptomyces lydicus, showing differential assembly and mixed shell formation with irregular tiling.

Point mutation in a virus-like capsid drives symmetry reduction to form tetrahedral cages

The paper shows that a single point mutation in a virus-like capsid can drive the formation of tetrahedral structures instead of the typical icosahedral symmetry.

Cyclodipeptide oxidase is an enzyme filament

The paper reports the structural characterization of the cyclodipeptide oxidase AlbAB from Streptomyces noursei, revealing it as a filamentous enzyme essential for antibiotic biosynthesis.

Structural basis for peroxidase encapsulation in a protein nanocompartment

This study determines the structural basis for encapsulating dye-decolorizing peroxidases in a protein nanocompartment using cryo-EM and mutagenesis.

HIV-1 binds dynein directly to hijack microtubule transport machinery

This study shows HIV-1 directly binds dynein to hijack microtubule transport for motility, bypassing traditional cargo adaptors.

Structure and heterogeneity of a highly cargo-loaded encapsulin shell

The paper reports the cryo-EM structure of a highly cargo-loaded encapsulin shell and identifies structural distortions caused by high cargo loading.

A widespread proteinaceous sulfur storage compartment in bacteria

The paper identifies desulfurase encapsulins as a novel sulfur storage compartment in bacteria, showing they sequester elemental sulfur and enhance desulfurase activity.

Exploring the Extreme Acid Tolerance of a Dynamic Protein Nanocage

This study characterizes AaEnc, an acid-stable encapsulin nanocage from Acidipropionibacterium acidipropionici, revealing its pH-dependent dynamic pore and extreme acid tolerance.

Large-scale computational discovery and analysis of virus-derived microbial nanocompartments

The paper identifies and analyzes over 6,000 encapsulin-like systems across bacterial and archaeal phyla, revealing novel families and operons, and proposes evolutionary links to HK97-type bacteriophages.