Author

M. P. Macedo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Immunology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell-cell communication· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2

Frequent Co-Authors

C. Penha-Goncalves· 2 shared I. Coelho· 2 shared N. Duarte· 2 shared A. Barros· 1 shared A. S. Carvalho· 1 shared A. Teshima· 1 shared B. C. Silva· 1 shared H. C. Beck· 1 shared

Activity by Year

2019-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

C. Penha-Goncalves

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Messages From the Small Intestine Carried by Extracellular Vesicles in Prediabetes: a Proteomic Portrait

I. Ferreira, R. M. de Oliveira, A. S. Carvalho, A. Teshima, H. C. Beck, R. Matthiesen, B. C. Silva, M. P. Macedo

This study identifies changes in the proteome of gut-derived extracellular vesicles in prediabetic mice, showing altered protein packaging that may transmit metabolic signals to other tissues.

bioRxiv · Feb 19, 2021Pathology

Pre-diabetes linked microRNA miR-193b-3p targets PPARGC1A and increases lipid accumulation in hepatocytes: potential biomarker of fatty liver disease

I. G. Mollet, M. P. Macedo

This study shows that miR-193b-3p targets PPARGC1A, disrupts metabolic pathways, and increases lipid accumulation in hepatocytes, suggesting it as a potential biomarker for fatty liver disease in pre-diabetes.

bioRxiv · Jan 22, 2021 · PreprintBiochemistry

Trem-2 modulation of gut microbiota is blunted during hepatotoxic injury and uncoupled from liver repair responses

I. Coelho, N. Duarte, M. P. Macedo, C. Penha-Goncalves

This study shows that Trem-2 modulates gut microbiota composition but this effect is uncoupled from its protective role in liver repair during hepatotoxic injury.

bioRxiv · Nov 28, 2019 · PreprintMicrobiology

Trem-2 promotes emergence of restorative macrophages and endothelial cells during recovery from hepatic tissue damage.

I. Coelho, N. Duarte, A. Barros, M. P. Macedo, C. Penha-Goncalves

This study shows Trem-2 promotes the transition of liver macrophages to restorative phenotypes and influences endothelial cell de-differentiation during liver recovery from injury.

bioRxiv · Oct 30, 2019Immunology