Author

I. Ferreira

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Cell Biology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

B. Meng· 4 shared D. Collier· 3 shared G. Papa· 3 shared P. Mlcochova· 3 shared A. Abdullahi· 2 shared J. Hyeon Lee· 2 shared L. James· 2 shared O. Charles· 2 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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Curved chords = mutual co-authorship

4 shared papersMicrobiology

B. Meng

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Hypoxia drives HIF2-dependent macrophage cell cycle entry and susceptibility to lentiviral transduction

B. Meng, N. Zhao, P. Mlcochova, I. Ferreira, B. Ortmann, T. Davis, J. Rehwinkle, S. Cook, P. Maxwell, J. Nathan, R. K. Gupta

This study shows hypoxia induces HIF2-dependent cell cycle entry in macrophages, leading to increased susceptibility to lentiviral transduction and is observed in tumor-associated macrophages.

bioRxiv · Dec 15, 2023 · PreprintCell Biology

In Vitro Inhibition of SARS-CoV-2 Infection by Bromhexine hydrochloride

R. Martins, I. Ferreira, D. M. Jorge, L. Almeida, J. d. P. Souza, M. C. Pontelli, I. A. Castro, T. Melquiades, R. M. Mendes Viana, D. S. Zamboni, P. Marcato, E. Arruda

This study shows bromhexine hydrochloride inhibits SARS-CoV-2 infection in vitro by targeting TMPRSS2, reducing viral entry and progeny without direct virucidal activity.

bioRxiv · Dec 23, 2022 · PreprintPharmacology & Toxicology

SARS-CoV-2 Omicron spike mediated immune escape, infectivity and cell-cell fusion

B. Meng, I. Ferreira, A. Abdullahi, N. Goonawardane, A. Saito, I. Kimura, D. Yamasoba, S. A. Kemp, G. Papa, S. Fatihi, S. Rathore, P. Perera Gerba, T. Ikeda, M. Toyoda, T. S. Tan, , S. Zepeda

This study investigates the immune escape, infectivity, and cell-cell fusion properties of SARS-CoV-2 Omicron BA.1 compared to Delta, showing higher ACE2 affinity and antibody evasion but similar antiviral drug efficacy.

bioRxiv · Dec 17, 2021Microbiology

SARS-CoV-2 B.1.617.2 Delta variant replication, sensitivity to neutralising antibodies and vaccine breakthrough

P. Mlcochova, S. A. Kemp, M. Shanker Dhar, G. Papa, B. Meng, S. Mishra, C. Whittaker, T. Mellan, I. Ferreira, R. Datir, D. Collier, S. Singh, R. Pandey, K. Ponnusamy, V. S. Radhakrishnan, , Saliba

This study evaluates the replication, antibody sensitivity, and vaccine efficacy of the SARS-CoV-2 B.1.617.2 Delta variant compared to other variants and vaccine-elicited immunity.

bioRxiv · May 8, 2021 · PreprintMicrobiology

Messages From the Small Intestine Carried by Extracellular Vesicles in Prediabetes: a Proteomic Portrait

I. Ferreira, R. M. de Oliveira, A. S. Carvalho, A. Teshima, H. C. Beck, R. Matthiesen, B. C. Silva, M. P. Macedo

This study identifies changes in the proteome of gut-derived extracellular vesicles in prediabetic mice, showing altered protein packaging that may transmit metabolic signals to other tissues.

bioRxiv · Feb 19, 2021Pathology

Recurrent emergence and transmission of a SARS-CoV-2 Spike deletion H69/V70

S. Kemp, B. Meng, I. Ferreira, R. Datir, W. Harvey, D. Collier, COVID-19 Genomics UK (COG-UK) consortium, G. Papa, A. Carabelii, S. Lytras, J. Kenyon, A. Lever, L. James, D. L. Robertson, R. K. Gupta

This paper identifies a recurrent SARS-CoV-2 Spike deletion (H69/V70) that increases infectivity and compensates for RBD mutations, suggesting it may facilitate immune escape and variant emergence.

bioRxiv · Dec 14, 2020Microbiology