HSPA8 chaperone complex drives chaperone-mediated autophagy regulation in acute promyelocytic leukemia differentiation
S. Rafiq, I. Mungure, N. J. Niklaus, S. Mueller, A. Jacquel, G. Robert, P. Auberger, B. E. Torbett, S. Muller, M. P. Tschan, M. Humbert
This study shows that HSPA8 chaperone complex regulates chaperone-mediated autophagy (CMA) during APL differentiation, with CMA downregulation required for neutrophil maturation.
bioRxiv · Aug 7, 2022 · PreprintCancer Biology