S. Muller

Nodule organogenesis in Medicago truncatula requires local stage-specific auxin biosynthesis and transport

This study shows that auxin biosynthesis and transport genes are dynamically expressed during nodule formation in Medicago truncatula, creating auxin gradients essential for nodule development.

Acute effects of psilocybin on the dynamics of gaze fixations during visual aesthetic perception

This study examines how psilocybin affects eye movements during aesthetic perception, finding that high doses lead to more localized visual exploration and reduced fixation entropy.

"Candidatus Siderophilus nitratireducens": a psychrophilic, nap-dependent nitrate-reducing iron oxidizer within the new order Siderophiliales

The paper identifies a new nitrate-reducing iron-oxidizing bacterium in groundwater, demonstrating its lithoautotrophic growth and metabolic pathway.

Meta-omics profiling of full-scale groundwater rapid sand filters explains stratification of iron, ammonium and manganese removals

The paper uses metaproteomics to analyze full-scale groundwater filters and shows how microbial protein expression stratifies with nutrient availability, explaining iron, ammonium, and manganese removal patterns.

Origin, exposure routes and xenobiotics impart nanoplastics with toxicity on freshwater bivalves

This study tests the toxicity of environmentally aged nanoplastics on freshwater bivalves and finds that trophic and synergistic exposures cause more gene modulations than direct exposure, with NP-PS being more harmful at high concentrations.

Mapping the landscape of genetic dependencies in chordoma

This study identifies essential genes in chordoma using CRISPR screens, revealing new therapeutic targets like PTPN11 and confirming known dependencies such as TBXT.

HSPA8 chaperone complex drives chaperone-mediated autophagy regulation in acute promyelocytic leukemia differentiation

This study shows that HSPA8 chaperone complex regulates chaperone-mediated autophagy (CMA) during APL differentiation, with CMA downregulation required for neutrophil maturation.

Discovery of a druggable copper-signaling pathway that drives cell plasticity and inflammation

The paper identifies a copper-signaling pathway involving CD44 and mitochondrial copper(II) that drives inflammation and cell plasticity, and shows a metformin-based drug reduces inflammation in infection models.

Natural language signatures of psilocybin microdosing

This study uses natural language analysis to detect psilocybin microdosing effects, finding significant differences in speech metrics between active and placebo conditions.

CLUH controls astrin-1 expression to couple mitochondrial metabolism to cell cycle progression

This study shows CLUH regulates astrin-1 expression to link mitochondrial metabolism with cell cycle progression.

Global Plant Extinction Risk Assessment Informs Novel Biodiversity Hotspots

This paper uses AI to predict extinction risk for all vascular plants and identifies new biodiversity hotspots for conservation.

Stabilising microbial communities by looped mass transfer

This study introduces a looped mass transfer system to stabilize microbial communities, showing that it reduces stochastic fluctuations and supports subcommunities with zero net growth.

CHROMOMETHYLTRANSFERASE3/KRYPTONITE maintain the sulfurea paramutation in Solanum lycopersicum

The paper shows that CMT3 and KRYPTONITE maintain the sulfurea paramutation in tomato by affecting CHG hypermethylation and chromatin structure, but not the PolV-dependent RdDM pathway.

Lipoic acid biosynthesis is essential for Plasmodium falciparum transmission and influences redox response and carbon metabolism of parasite asexual blood stages

Viral fitness determines the magnitude of transcriptomic and epigenomic reprogramming of defense responses in plants

The paper investigates how viral adaptation affects transcriptomic and epigenomic changes in Arabidopsis thaliana during antiviral responses, finding that DNA methylation and histone modifications play a role in defense.

The Kinase Chemogenomic Set (KCGS): An open science resource for kinase vulnerability identification

The paper introduces the Kinase Chemogenomic Set (KCGS), a curated collection of 187 selective kinase inhibitors covering 215 human kinases, for use in cell-based screens.

CD44 regulates epigenetic plasticity by mediating iron endocytosis

This study identifies CD44 as a mediator of iron endocytosis linked to epigenetic plasticity, showing iron's role in regulating histone modifications and gene expression during mesenchymal transitions.

A draft single-cell atlas of human glioblastoma reveals a single axis of phenotype in tumor-propagating cells.

This study constructs a single-cell atlas of human glioblastoma, revealing a single axis of variation in tumor-propagating cells and linking mesenchymal GSCs to poor prognosis.

Progress Towards a Public Chemogenomic Set for Protein Kinases and a Call for Contributions

The paper shares progress on a kinase chemogenomic set, releases inhibitor profiling data, and calls for community collaboration to complete the set.