M. P. Y. Lam

The paper analyzes mass spectrometry data to identify alternative splicing-derived protein variants in human heart chambers, finding tissue-specific isoforms and their functional implications in protein binding.

This study introduces SPLAT, a proteomics method to analyze protein turnover and localization simultaneously, revealing spatiotemporal changes in the unfolded protein response in human cells.

This study uses proteogenomics to identify age and sex-dependent gene expression and splicing changes in mouse hearts, revealing sexual dimorphism in cardiac aging and regulatory networks.

The paper identifies transcriptomic signatures in aging striated muscle that predict protein level changes and prioritizes genes with age-dependent expression in humans.

This study identifies proteomic changes in mouse hearts after paraquat exposure, showing mitochondrial dysfunction and antioxidant activation, with limited overlap with lung responses.