Role of transporters and enzymes in metabolism and distribution of 4-chlorokynurenine and metabolites
W. Patel, R. G. Shankar, M. A. Smith, H. R. Snodgrass, M. Pirmohamed, A. Jorgensen, A. Alfirevic, D. Dickens
The paper investigates the metabolism and distribution of 4-chlorokynurenine and its metabolites, identifying a novel acetylated metabolite and pharmacogenetic associations affecting drug levels and transporter interactions.
bioRxiv · Jul 14, 2023 · PreprintPharmacology & Toxicology