Author

M. A. Smith

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Bioengineering· 3 Ecology· 2 Immunology· 2 Animal Behavior & Cognition· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 11 Research Focus:cell type annotation· 8 Organism:human· 8 Approach:statistical model· 8 Research Focus:differential expression· 4 Research Focus:gene regulatory network inference· 4 Assay:imaging· 4 Organism:non-human primate· 4

Frequent Co-Authors

B. Wang· 3 shared G. Wollstein· 3 shared H. Ishikawa· 3 shared I. A. Sigal· 3 shared J. S. Schuman· 3 shared S. E. Schmitt· 3 shared A. Modi· 2 shared A. Pustilnik· 2 shared

Activity by Year

2016-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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3 shared papersBioengineering

B. Wang

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Author profile →

18 papers

Recent·Most cited

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma

A. K. Weiner, A. B. Radaoui, M. Tsang, D. Martinez, S. Sidoli, K. L. Conkrite, A. Delaidelli, A. Modi, J. L. Rokita, K. Patel, M. V. Lane, B. Zhang, C. Zhong, B. Ennis, D. P. Miller, , S. J. Diskin

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

bioRxiv · Dec 6, 2023 · PreprintCancer Biology

Role of transporters and enzymes in metabolism and distribution of 4-chlorokynurenine and metabolites

W. Patel, R. G. Shankar, M. A. Smith, H. R. Snodgrass, M. Pirmohamed, A. Jorgensen, A. Alfirevic, D. Dickens

The paper investigates the metabolism and distribution of 4-chlorokynurenine and its metabolites, identifying a novel acetylated metabolite and pharmacogenetic associations affecting drug levels and transporter interactions.

bioRxiv · Jul 14, 2023 · PreprintPharmacology & Toxicology

A framework for linking hemispheric, full annual cycle prioritizations to local conservation actions for migratory birds

W. V. Deluca, N. E. Seavy, J. Grand, J. Velasquez-Tibat, L. Taylor, C. Bowler, J. L. Deppe, E. J. Knight, G. M. Lentijo, T. D. Meehan, N. L. Michel, S. P. Saunders, N. Schillerstrom, M. A. Smith, C. Witko, C. B. Wilsey

This paper presents a framework to connect hemispheric migratory bird conservation priorities with local actions, using examples from North and South Carolina and Colombia.

bioRxiv · Apr 3, 2023Ecology

Diffsig: Associating Risk Factors With Mutational Signatures

J.-E. Park, M. A. Smith, S. C. Van Alsten, A. Walens, D. Wu, K. A. Hoadley, M. A. Troester, M. I. Love

Diffsig estimates associations between risk factors and mutational signatures using a Bayesian model, confirming known cancer mechanisms in breast cancer data.

bioRxiv · Feb 9, 2023Cancer Biology

In vivo Modulation of Intraocular and Intracranial Pressures Causes Nonlinear and Non-monotonic Deformations of the Lamina Cribrosa and Scleral Canal

Z. Zhu, S. Waxman, B. Wang, J. Wallace, S. E. Schmitt, E. Tyler-Kabara, H. Ishikawa, J. S. Schuman, M. A. Smith, G. Wollstein, I. A. Sigal

This study examines how changes in intraocular and intracranial pressures affect monkey optic nerve head morphology, finding nonlinear and non-monotonic deformations not explained by translaminar pressure difference.

bioRxiv · Jan 29, 2023 · PreprintBioengineering

Comparing acute IOP-induced lamina cribrosa deformations pre-mortem and post-mortem

J. Wei, Y. Hua, B. Yang, B. Wang, S. E. Schmitt, B. Wang, K. A. Lucy, H. Ishikawa, J. S. Schuman, M. A. Smith, G. Wollstein, I. A. Sigal

The paper compares acute IOP-induced lamina cribrosa deformations in monkeys pre-mortem and post-mortem, finding similar trends but smaller pre-mortem deformations overall with local variations.

bioRxiv · Sep 18, 2022 · PreprintBioengineering

Tissue-Like 3D Standard and Protocols for Microscope Quality Management

B. Abrams, T. Pengo, T. L. Wee, R. C. Deagle, N. Vuillemin, L. M. Callahan, M. A. Smith, K. E. Kubow, A.-M. Girard, J. Z. Rappoport, C. J. Bayles, L. A. Cameron, R. Cole, C. M. Brown

The paper introduces a 3D tissue-like standard for fluorescence microscope quality assessment, showing reproducible results across labs and equipment.

bioRxiv · Aug 14, 2022Cell Biology

Molecular basis for antiviral activity of pediatric neutralizing antibodies targeting SARS-CoV-2 Spike receptor binding domain

Y. Chen, J. Prevost, I. Ullah, H. Romero, V. Lisi, W. D. Tolbert, J. R. Grover, S. Ding, S. Y. Gong, G. Beaudoin-Bussieres, R. Gasser, M. Benlarbi, D. Vezina, S. P. Anand, D. Chatterjee, , A. Finzi

This study identifies two potent neutralizing antibodies, EH3 and EH8, from a pediatric patient that cross-neutralize SARS-CoV-2 variants and provide in vivo protection against the Delta VOC.

bioRxiv · Jul 27, 2022 · PreprintMicrobiology

Hue tuning curves in V4 change with visual context

A. S. Benjamin, P. Ramkumar, H. Fernandes, M. A. Smith, K. P. Kording

The paper shows that hue tuning in macaque V4 neurons measured with simple stimuli does not correlate with tuning in natural scenes, suggesting mixed selectivity enhances information transmission.

bioRxiv · Jan 9, 2022 · PreprintNeuroscience

LY-CoV1404 (bebtelovimab) potently neutralizes SARS-CoV-2 variants

K. Westendorf, S. Zentelis, L. Wang, D. Foster, P. Vaillancourt, M. Wiggin, E. Lovett, R. van der Lee, J. Hendle, A. Pustilnik, J. M. Sauder, L. Kraft, Y. Hwang, R. W. Siegel, J. Chen, , Ramamurt

This paper identifies LY-CoV1404, a potent SARS-CoV-2 neutralizing antibody effective against multiple variants, including Omicron and Delta, due to its conserved epitope and resistance to common mutations.

bioRxiv · Apr 30, 2021Immunology

Interplay between intraocular and intracranial pressure effects on the optic nerve head in vivo

Z. Zhu, S. Waxman, B. Wang, J. Wallace, S. E. Schmitt, E. Tyler-Kabara, H. Ishikawa, J. S. Schuman, M. A. Smith, G. Wollstein, I. A. Sigal

This study measures how changes in intraocular and intracranial pressure affect the optic nerve head in monkeys using OCT, showing significant interactions between the pressures.

bioRxiv · Dec 14, 2020Bioengineering

Integrative genomics identifies lncRNA regulatory networks across 1,044 pediatric leukemias and extra-cranial solid tumors

A. Modi, G. Lopez, K. L. Conkrite, C. Su, T. C. Leung, S. Ramanan, E. Manduchi, M. E. Johnson, D. Cheung, S. Gadd, J. Zhang, M. A. Smith, J. M. Guidry Auvil, D. S. Gerhard, S. Meshinchi, , S. J. Diskin

The paper identifies lncRNA regulatory networks in pediatric cancers using integrated genomics data from 1,044 samples, revealing their roles in proliferation, metabolism, and DNA damage.

bioRxiv · Dec 10, 2020 · PreprintCancer Biology

The Effects of Strain and Estrous Cycle on Heroin- and Sucrose-Maintained Responding in Female Rats

K. T. Schmidt, J. L. Sharp, S. B. Ethridge, T. Pearson, S. Ballard, K. M. Potter, M. A. Smith

This study shows that heroin intake, but not sucrose intake, decreases during proestrus in female rats across three strains.

bioRxiv · Nov 6, 2020Animal Behavior & Cognition

LY-CoV555, a rapidly isolated potent neutralizing antibody, provides protection in a non-human primate model of SARS-CoV-2 infection

B. E. Jones, P. L. Brown-Augsburger, K. S. Corbett, K. Westendorf, J. Davies, T. P. Cujec, C. M. Wiethoff, J. L. Blackbourne, B. A. Heinz, D. Foster, R. E. Higgs, D. Balasubramaniam, L. Wang, R. Bidshahri, L. Kraft, , M. de Vries

LY-CoV555, an anti-spike antibody from a convalescent COVID-19 patient, neutralizes SARS-CoV-2 and protects non-human primates against infection.

bioRxiv · Sep 30, 2020Immunology

Parasitoid community responds indiscriminately to fluctuating spruce budworm and other caterpillars on balsam fir

C. J. Greyson-Gaito, K. S. McCann, J. Fründ, C. J. Lucarotti, M. A. Smith, E. S. Eveleigh

The study shows parasitoid communities respond linearly and indiscriminately to budworm and caterpillar density fluctuations, altering interaction strengths and food web pathways.

bioRxiv · Apr 15, 2020 · PreprintEcology

Mechanosensing through direct binding of tensed F-actin by LIM domains

X. Sun, D. Y. Z. Phua, L. Axiotakis, M. A. Smith, E. Blankman, R. Gong, R. C. Cail, S. Espinosa de los Reyes, M. C. Beckerle, C. M. Waterman, G. M. Alushin

The paper identifies LIM domains' direct binding to tensed F-actin as a mechanosensing mechanism, showing force-dependent sequestration affects nuclear localization.

bioRxiv · Mar 6, 2020Biophysics

Comprehensive characterization of pediatric AML reveals diverse fusion oncoproteins and age-specific mutational interactions

H. Bolouri, J. E. Farrar, T. J. Triche, R. E. Ries, E. L. Lim, T. A. Alonzo, Y. Ma, R. Moore, A. Mungall, M. A. Marra, J. Zhang, X. Ma, Y. Liu, Y. Liu, J. M. Guidry Auvil, , S. Meshinchi

This study characterizes the molecular landscape of pediatric AML, identifying age-specific mutations and fusion oncoproteins that differ from adult AML.

bioRxiv · Oct 10, 2017Cancer Biology

E-scape: Interactive visualization of single cell phylogenetics and spatio-temporal evolution in cancer

M. A. Smith, C. Nielsen, F. C. Chan, A. McPherson, A. Roth, H. Farahani, D. Machev, A. Steif, S. P. Shah

E-scape provides an interactive visualization tool for analyzing cancer clonal dynamics and spatio-temporal evolution using integrated mutation, phylogenetic, and imaging data.

bioRxiv · Nov 20, 2016Cancer Biology