A human tubular aggregate myopathy mutation unmasks STIM1-independent rapid inactivation of Orai1 channels
P. S.-W. Yeung, M. Yamashita, M. Prakriya
The paper investigates a human Orai1 mutation causing tubular aggregate myopathy and shows that Ca2+-dependent inactivation (CDI) of CRAC channels can occur independently of STIM1.
bioRxiv · Aug 12, 2022Physiology