Author

M. R. Machado

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 3 Approach:experimental assay· 2 Research Focus:protein structure prediction· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

S. Pantano· 3 shared A. Zeida· 1 shared C. E. Edwards· 1 shared E. E. Barrera· 1 shared E. E. Barrera Guisasola· 1 shared F. Klein· 1 shared H. Verli· 1 shared J. Yang· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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3 shared papersBiophysics

S. Pantano

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Thiol-based mucolytics exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein

Y. Shi, A. Zeida, C. E. Edwards, M. L. Mallory, S. Sastre, M. R. Machado, R. J. Pickles, L. Fu, K. Liu, J. Yang, R. S. Baric, R. C. Boucher, R. Radi, K. S. Carroll

This study shows thiol-based mucolytics inhibit SARS-CoV-2 by disrupting disulfides in the spike protein, reducing ACE2 binding and viral infection.

bioRxiv · Jul 1, 2021Microbiology

SIRAH late harvest:coarse-grained models for protein glycosylation

P. G. Garay, M. R. Machado, H. Verli, S. Pantano

The paper introduces a coarse-grained model for protein glycosylation compatible with the SIRAH force field, demonstrating its application to N-glycosylated proteins and glycan-protein interactions.

bioRxiv · Dec 18, 2020Biophysics

Fat SIRAH: Coarse-grained phospholipids to explore membrane-protein dynamics.

E. E. Barrera, M. R. Machado, S. Pantano

The paper introduces a new parameterization of coarse-grained phospholipids for the SIRAH force field, enabling accurate simulation of membrane-protein dynamics and interactions.

bioRxiv · May 5, 2019Biophysics

The SIRAH force field 2.0: Altius, Fortius, Citius

M. R. Machado, E. E. Barrera Guisasola, F. Klein, M. Sonora, S. Silva, S. Pantano

The paper introduces an updated coarse-grained SIRAH force field for proteins, demonstrating its ability to accurately model structural and dynamic behaviors of calcium-binding proteins like Calmodulin.

bioRxiv · Oct 5, 2018Biophysics