Author

R. J. Pickles

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:imaging· 1

Frequent Co-Authors

R. C. Boucher· 2 shared R. S. Baric· 2 shared S. H. Randell· 2 shared A. M. Cawley· 1 shared A. Zeida· 1 shared B. R. Grubb· 1 shared C. A. Lewis· 1 shared C. E. Edwards· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersBioengineering

R. C. Boucher

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Prolonged airway explant culture enables study of health, disease, and viral pathogenesis

R. E. Lee-Ferris, K. Okuda, J. R. Galiger, S. A. Schworer, T. D. Rogers, H. Dang, R. Gilmore, C. Edwards, S. Nakano, A. M. Cawley, R. J. Pickles, S. C. Gallant, E. Crisci, L. Rivier, J. S. Hagood, , S. H. Randell

This study develops methods to culture human and animal airway explants for at least 14 days, preserving tissue architecture and enabling study of health, disease, and viral infection.

bioRxiv · Feb 3, 2024Bioengineering

Viral Airway Injury Promotes Cell Engraftment in an In Vitro Model of Cystic Fibrosis Cell Therapy

R. E. Lee, T. M. Mascenik, S. C. Major, C. A. Lewis, J. E. Bear, R. J. Pickles, S. H. Randell

This study shows that viral airway injury enhances cell engraftment in an in vitro CF model by creating conditions that favor non-CF cell integration and functional CFTR recovery.

bioRxiv · Nov 14, 2022 · PreprintCell Biology

Thiol-based mucolytics exhibit antiviral activity against SARS-CoV-2 through allosteric disulfide disruption in the spike glycoprotein

Y. Shi, A. Zeida, C. E. Edwards, M. L. Mallory, S. Sastre, M. R. Machado, R. J. Pickles, L. Fu, K. Liu, J. Yang, R. S. Baric, R. C. Boucher, R. Radi, K. S. Carroll

This study shows thiol-based mucolytics inhibit SARS-CoV-2 by disrupting disulfides in the spike protein, reducing ACE2 binding and viral infection.

bioRxiv · Jul 1, 2021Microbiology