M. Reddy

Mapping Endothelial-Macrophage Interactions in Diabetic Vasculature: Role of TREM2 in Vascular Inflammation and Ischemic Response

This study maps endothelial-macrophage interactions in diabetic vasculature using single-cell and spatial transcriptomics, identifying TREM2 as a key driver of vascular inflammation and ischemic response in diabetes.

Glycan strand cleavage by a lytic transglycosylase, MltD contributes to the expansion of peptidoglycan in Escherichia coli

This study identifies MltD as a glycan cleaving enzyme that compensates for the absence of cross-link cleavage enzymes in E. coli, contributing to peptidoglycan expansion.

A novel LC-MS/MS method development and validation for the determination of tezepelumab in rat plasma and its application in rat pharmacokinetic studies

This paper develops and validates an LC-MS/MS method for quantifying tezepelumab in rat plasma and applies it to pharmacokinetic studies.

Modulation of RecFORQ- and RecA-mediated homologous recombination in Escherichia coli by isoforms of translation initiation factor IF2

The paper shows that IF2-1 modulates RecFORQ- and RecA-mediated homologous recombination in E. coli, suppressing synthetic lethality in uvrD-ruv and rho-ruv mutants.

Cleavage of Braun lipoprotein Lpp from the bacterial peptidoglycan by a paralog of L,D-transpeptidases, LdtF

This paper identifies LdtF as a murein endopeptidase that cleaves Lpp from peptidoglycan in E. coli, revealing its role in modulating outer membrane-peptidoglycan linkages.

Structural basis for the differential regulatory roles of the PDZ domain in C-terminal processing proteases

The paper reveals the structural basis for the differential regulatory roles of the PDZ domain in C-terminal processing proteases through structural and functional analysis.