D. Yuan

A Stapled Peptide Inhibitor of METTL3-METTL14 for Cancer Therapy

This paper develops a stapled peptide inhibitor of METTL3-METTL14 that suppresses tumor growth by inhibiting m6A methylation and promoting METTL3 degradation.

ID1 functions as an autonomous phosphate (Pi) regulator upstream of the miR399-ZmPHO2 signaling module in maize

The paper identifies ID1 as an autonomous phosphate regulator that modulates the miR399-ZmPHO2 signaling module to maintain Pi homeostasis in maize.

Dissecting the genetic basis of the heterosis of Y900, an elite super-hybrid rice

The paper identifies genetic and regulatory mechanisms underlying heterosis in the rice hybrid Y900 by analyzing genome and transcriptome data from its parental lines.

Accurate background reduction in adaptive optical 3D-STED nanoscopy by dynamic phase switching

This paper introduces a method to improve signal-to-background ratio in 3D-STED nanoscopy using dynamic phase switching with adaptive optics.

An in situ quantitative map of initial human colorectal HIV transmission

This study quantifies HIV transmission dynamics in human colorectal tissue, showing HIV localizes to mucosal dendritic cells and submucosal macrophages rather than CD4+ T-cells.

Structure of IgG-Fc hexamer reveals a mutual lock-and-key mode of Fc-Fc interaction

The paper determines the structure of an IgG-Fc hexamer using cryo-EM, revealing a mutual lock-and-key interaction mode between Fc domains.

Dual domestication, diversity, and differential introgression in Old World cotton diploids

This study investigates the domestication and genetic diversity of two diploid cotton species, confirming independent domestication and identifying patterns of introgression and chromosomal variability.

An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

This study shows that an intranasal vaccine provides durable protection against SARS-CoV-2 variants in mice, including emerging strains like B.1.351 and B.1.1.28.

Collaboration between the Fab and Fc contribute to maximal protection against SARS-CoV-2 in nonhuman primates following NVX-CoV2373 subunit vaccine with Matrix-M™ vaccination

This study shows that NVX-CoV2373 vaccine induces antibodies with both neutralizing and Fc-effector functions, which together provide maximal protection against SARS-CoV-2 in non-human primates.

Gene mutations in members of the PI3K/Akt signalling pathway are related to immune thrombocytopenia pathogenesis

This study identifies gene mutations in the PI3K/Akt pathway associated with immune thrombocytopenia (ITP) using whole-exome sequencing and functional analysis.

Parietal cell-Specific SLC26A9 Deletion induces spontaneous Gastric Carcinogenesis in Mice

This study shows that deleting Slc26a9 in parietal cells of mice leads to spontaneous gastric cancer and identifies molecular mechanisms involved in tumor progression.

Multiomic Immunophenotyping of COVID-19 Patients Reveals Early Infection Trajectories

This study integrates multi-omic data from COVID-19 patients to identify immune response patterns linked to disease severity.

Modern human origins: multiregional evolution of autosomes and East Asia origin of Y and mtDNA

The paper challenges the Recent Out of Africa model by proposing multiregional evolution of autosomes and East Asian origin of modern Y and mtDNA through hybridization with archaic humans.

Accumulation of Minor Alleles of Common SNPs in Schizophrenia

The paper investigates the role of minor alleles in schizophrenia using public datasets, finding higher minor allele content in cases and identifying SNPs that predict schizophrenia with 100% certainty.

Genetic equidistance at the nucleotide level

The paper examines genetic equidistance at the DNA level across 15 proteomes, confirming the maximum genetic diversity hypothesis and showing species complexity, not time, determines equidistance.