S. Yin

MdfA is a novel ClpC adaptor protein that functions in the developing Bacillus subtilis spore

This study identifies MdfA as a ClpC adaptor protein in Bacillus subtilis that promotes spore metabolic dormancy by inducing ClpCP-mediated degradation of metabolic enzymes.

Unveiling chemotherapy-induced immune landscape remodeling and metabolic reprogramming in lung adenocarcinoma by scRNA-sequencing

This study uses scRNA-seq to analyze how chemotherapy remodels the immune landscape and metabolic state in lung adenocarcinoma, identifying changes in macrophage subtypes and immune responses.

Investigating 3D microbial community dynamics in the rhizosphere using complex-field and fluorescence microscopy

This paper introduces CFAST, a novel imaging technique for 3D microbial community dynamics in the rhizosphere, enabling non-invasive tracking of bacterial behavior and gene expression without genetic labeling.

PHOSPHATE-INDUCED 1 and its paralogs positively regulate cellulose biosynthesis in Arabidopsis.

This study shows that PHOSPHATE-INDUCED 1 and its paralogs regulate cellulose biosynthesis in Arabidopsis by modulating CSC activity in response to developmental and environmental cues.

Oncogenic PIK3CA corrupts growth factor signaling specificity

The paper uses single-cell analyses to show that oncogenic PIK3CAH1047R reduces IGF1 signaling specificity and enhances EGF responses, leading to increased phenotypic heterogeneity.

SARS-CoV-2 Omicron infection augments the magnitude and durability of systemic and mucosal immunity in triple-dose CoronaVac recipients

This study examines immune responses in CoronaVac-vaccinated individuals after Omicron infection, showing enhanced antibody and cellular immunity compared to unvaccinated controls.

Histone chaperone HIRA, Promyelocytic Leukemia (PML) protein and p62/SQSTM1 coordinate to regulate inflammation during cell senescence.

This study shows HIRA and PML regulate SASP through interactions with p62/SQSTM1 and the cGAS-STING pathway in senescent cells.

Functional Relations of CSLD2, CSLD3, and CSLD5 Proteins during Cell Wall Synthesis in Arabidopsis

This study investigates the functional roles of CSLD2, CSLD3, and CSLD5 proteins in cell wall synthesis in Arabidopsis, showing their conserved {beta}-1,4 glucan synthase activities and distinct contributions to cell plate formation.

Integrated Cell Landscape and Dynamics in the Progression of Bone Repair

The paper maps cell landscape and dynamics in rodent bone repair using single-cell RNA sequencing and identifies functional roles of myeloid and lymphoid cells in osteogenesis and angiogenesis.

Plasma membrane association and resistosome formation of plant helper immune receptors

This study identifies the role of positively charged residues in helper NLRs for phospholipid binding and plasma membrane association, and shows effector activation induces NRG1 oligomerization at the plasma membrane.

KARS mediates intra-translational deposition of N6-acetyl-L-lysine in nascent proteins to contribute the acetylome in cells

The paper identifies KARS as mediating intra-translational deposition of N6-acetyl-L-lysine in nascent proteins, contributing to the acetylome in mice.

Structure-Kinetic Relationship for Drug Design Revealed by PLS Model with Retrosynthesis-Based Pre-trained Molecular Representation and Molecular Dynamics Simulation

This paper develops a PLS model combining retrosynthesis-based molecular representations and MD simulations to predict koff values for HSP90 inhibitors, showing high correlation with experimental data.

Habitat loss exacerbates pathogen spread: An Agent-based model of avian influenza infection in migratory waterfowl

This study uses an agent-based model to show that habitat loss in migratory waterfowl flyways can shift AIV outbreaks northward, increase outbreak risk, and enhance transmission among geese.

Strong and consistent associations of waterbird community composition with HPAI H5 occurrence in European wild birds

The paper shows that waterbird community composition strongly predicts HPAI H5 occurrence in wild birds across different epidemics, with similar patterns observed for H5N8 and H5N1.

Effects of Chronic Intermittent Hypoxia and Chronic Sleep Fragmentation on Gut Microbiome, Serum Metabolome, Liver and Adipose Tissue Morphology

This study examines how chronic intermittent hypoxia and chronic sleep fragmentation affect gut microbiota, serum metabolites, and tissue morphology in mice, revealing their impact on lipid metabolism.

Observing noncovalent interactions in experimental electron density for macromolecular systems: A novel perspective for protein-ligand interaction research

The paper introduces a database of non-covalent interactions in protein-ligand complexes using experimental electron density data and demonstrates its application in studying amide-pi interactions.

Cellular-level phenotyping of tumor-immune microenvironment (TiME) in patients in vivo reveals distinct inflammation and endothelial anergy signatures

The paper uses in vivo cellular-level imaging to phenotype tumor-immune microenvironments, identifying distinct inflammation and endothelial anergy signatures linked to immunotherapy response.

Amelioration of hemophilia B through CRISPR/Cas9 induced homology-independent targeted integration

This study uses CRISPR/Cas9 to induce homology-independent targeted integration in a rat hemophilia B model, achieving therapeutic correction with 3.66% knock-in efficiency and normalization of clotting time.

Keratin-Based Epidermal Green Autofluorescence is a Common Biomarker of Organ Injury

This study identifies keratin 1-based epidermal green autofluorescence as a biomarker for non-invasive assessment of inflammation and oxidative stress levels in the body.

Discovery of a new Neisseria gonorrhoeae Type IV pilus assembly factor, TfpC

This paper identifies TfpC as a new Neisseria gonorrhoeae protein essential for stabilizing Type IV pili in their extended form, with orthologs in other bacteria.

mTOR S-nitrosylation inhibits autophagy and lysosomal proteolysis

This study identifies mTOR S-nitrosylation as a kinase-independent mechanism that suppresses autophagy and lysosomal proteolysis, with implications for Alzheimer's disease.

An activity-guided map of electrophile-cysteine interactions in primary human immune cells

The paper maps electrophile-sensitive cysteines in primary human T cells and shows how electrophilic compounds affect T cell activation through cysteine modification.

PacBio amplicon sequencing method to measure pilin antigenic variation frequencies of Neisseria gonorrhoeae

Self-assembled primary tumor clusters for precision cancer therapy

This paper introduces a novel patient-derived tumor-like cell cluster model for personalized drug testing, showing high similarity to original tumors and enabling rapid drug testing within 10-20 days.

Highly multiplexed in situ protein imaging with signal amplification by Immuno-SABER

This paper introduces Immuno-SABER, a method for highly multiplexed protein imaging that overcomes limitations in sensitivity and throughput.