Author

M. S. Amaral

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Evolutionary Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:chicken / avian· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:comparative / phylogenetic analysis· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. A. Morales-Vicente· 2 shared D. S. Olivier· 2 shared D. Willbold· 2 shared R. J. Eberle· 2 shared R. K. Arni· 2 shared S. Verjovski-Almeida· 2 shared A. C. Tahira· 1 shared A. Soares-Schanoski· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersEvolutionary Biology

D. A. Morales-Vicente

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The human developing cerebral cortex is characterized by an increased de novo expression of lncRNAs in excitatory neurons

D. A. Morales-Vicente, A. C. Tahira, D. Woellner-Santos, M. S. Amaral, M. G. Berzoti-Coelho, S. Verjovski-Almeida

The paper identifies evolutionary shifts in lncRNA expression in the developing human cerebral cortex, showing increased de novo expression in excitatory neurons and associations with autism spectrum disorder.

bioRxiv · Oct 26, 2023Evolutionary Biology

Design of D-amino acids SARS-CoV-2 Main protease inhibitors using the cationic peptide from rattlesnake venom as a scaffold

R. J. Eberle, I. Gering, M. Tusche, P. N. Ostermann, L. Mueller, O. Adams, H. Schaal, D. S. Olivier, M. S. Amaral, R. K. Arni, D. Willbold, M. Coronado

The paper designs D-amino acid-based inhibitors of SARS-CoV-2 3CLpro using a rattlesnake venom peptide scaffold, showing in vitro and in vivo antiviral activity.

bioRxiv · Nov 10, 2021Biochemistry

The repurposed drugs suramin and quinacrine inhibit cooperatively in vitro SARS-CoV-2 3CLpro

R. J. Eberle, D. S. Olivier, M. S. Amaral, D. Willbold, R. K. Arni, M. A. Coronado

This study shows that quinacrine and suramin inhibit SARS-CoV-2 3CLpro synergistically in vitro through competitive and non-competitive mechanisms.

bioRxiv · Nov 11, 2020Biochemistry

Differential gene expression elicited by ZIKV infection in trophoblasts from congenital Zika syndrome discordant twins

M. S. Amaral, E. Goulart, L. C. Caires-Junior, D. A. Morales-Vicente, A. Soares-Schanoski, R. P. Gomes, G. G. O. Olberg, R. M. Astray, J. E. Kalil, M. Zatz, S. Verjovski-Almeida

This study compares gene expression in trophoblasts from CZS-affected and non-affected twins after ZIKV infection, finding differential regulation of genes related to cell adhesion and immune response.

bioRxiv · Dec 7, 2019Microbiology