Author

R. K. Arni

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:machine learning (classical)· 1 Approach:mechanistic / dynamical model· 1 Research Focus:metabolism & bioenergetics· 1 Assay:metabolomics· 1

Frequent Co-Authors

R. J. Eberle· 3 shared D. S. Olivier· 2 shared D. Willbold· 2 shared M. A. Coronado· 2 shared M. S. Amaral· 2 shared B. Stuqui· 1 shared F. R. de Moraes· 1 shared H. Schaal· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersBiochemistry

R. J. Eberle

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The secreted metabolome of HeLa cells under effect of Crotamine, a cell-penetrating peptide from a rattlesnake using NMR-based metabolomics analyses

M. A. Coronado, F. R. de Moraes, B. Stuqui, M. F. Calmon, R. J. Eberle, P. Rahal, R. K. Arni

This study uses NMR-based metabolomics to analyze how Crotamine affects the secreted metabolome of HeLa cells, revealing changes in glycolysis and related pathways.

bioRxiv · Jan 15, 2022Cell Biology

Design of D-amino acids SARS-CoV-2 Main protease inhibitors using the cationic peptide from rattlesnake venom as a scaffold

R. J. Eberle, I. Gering, M. Tusche, P. N. Ostermann, L. Mueller, O. Adams, H. Schaal, D. S. Olivier, M. S. Amaral, R. K. Arni, D. Willbold, M. Coronado

The paper designs D-amino acid-based inhibitors of SARS-CoV-2 3CLpro using a rattlesnake venom peptide scaffold, showing in vitro and in vivo antiviral activity.

bioRxiv · Nov 10, 2021Biochemistry

The repurposed drugs suramin and quinacrine inhibit cooperatively in vitro SARS-CoV-2 3CLpro

R. J. Eberle, D. S. Olivier, M. S. Amaral, D. Willbold, R. K. Arni, M. A. Coronado

This study shows that quinacrine and suramin inhibit SARS-CoV-2 3CLpro synergistically in vitro through competitive and non-competitive mechanisms.

bioRxiv · Nov 11, 2020Biochemistry