Author

M. S. Brennan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:benchmarking· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Strasser· 2 shared A. Janic· 1 shared C. Chang· 1 shared G. Dewson· 1 shared G. Healey· 1 shared G. L. Kelly· 1 shared G. Lessene· 1 shared K. Brinkmann· 1 shared

Activity by Year

2018-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCancer Biology

A. Strasser

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2 papers

Recent·Most cited

Combined absence of TRP53 target genes ZMAT3, PUMA and p21 cause a high incidence of cancer in mice

A. Janic, A. Strasser, M. Herold, M. S. Brennan, G. Healey, L. Gangoda, K. Brinkmann

The paper shows that combined absence of TRP53 target genes ZMAT3, PUMA, and p21 in mice leads to a higher incidence of cancer, with different tumor types depending on which genes are missing.

Cell Death & Differentiation · Dec 18, 2023Peer-reviewedCancer Biology

Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use

M. S. Brennan, C. Chang, G. Dewson, L. Tai, G. Lessene, A. Strasser, G. L. Kelly, M. J. Herold

This study develops a humanized Mcl-1 mouse model to evaluate MCL-1 inhibitors, showing improved sensitivity to S63845 and effective tumor remission in pre-clinical trials.

bioRxiv · Jun 14, 2018Cancer Biology