Author

M. Sacher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Organism:Drosophila· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Assay:metabolomics· 2 Organism:C. elegans· 1

Frequent Co-Authors

C. Gamberi· 2 shared M. P. Milev· 2 shared P. Asadi· 2 shared A. Naaz· 1 shared A. P. Wojtovich· 1 shared D. Saint-Dic· 1 shared E. S. Kim· 1 shared K. Youngs· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCell Biology

C. Gamberi

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Author profile →

3 papers

Recent·Most cited

Lipidomic analysis of human TANGO2-deficient cells suggests a lipid imbalance as a cause of TANGO2 deficiency disease

M. Mehranfar, P. Asadi, R. Shokohi, M. P. Milev, C. Gamberi, M. Sacher

This study identifies lipid imbalances in TANGO2-deficient human cells and shows vitamin B5 supplementation rescues these imbalances, suggesting a role for TANGO2 in lipid metabolism.

bioRxiv · Feb 29, 2024Cell Biology

Heme's relevance genuine? Re-visiting the roles of TANGO2 homologs including HRG-9 and HRG-10 in C. elegans

S. E. Sandkuhler, K. Youngs, O. Gottipali, L. Owlett, M. Bandora, A. Naaz, E. S. Kim, L. Wang, A. P. Wojtovich, V. A. Gupta, M. Sacher, S. J. Mackenzie

This study re-examines the role of TANGO2 homologs in C. elegans and finds that phenotypes previously linked to heme transport may instead reflect mitochondrial dysfunction and oxidative stress.

bioRxiv · Nov 29, 2023 · PreprintCell Biology

Vitamin B5, a Coenzyme A precursor, rescues TANGO2 deficiency disease associated defects in Drosophila and human cells

P. Asadi, M. P. Milev, D. Saint-Dic, C. Gamberi, M. Sacher

This paper shows that vitamin B5 rescues TANGO2 deficiency defects in Drosophila and human cells, suggesting potential therapeutic benefits for TANGO2-deficiency disease.

bioRxiv · Nov 4, 2022 · PreprintCell Biology