An Immunological Synapse Formation Between T Regulatory Cells and Cancer-Associated Fibroblasts Promotes Tumor Development
A. Varveri, M. Papadopoulou, Z. Papadovasilakis, E. B. Compeer, A. I. Legaki, A. Delis, V. Damaskou, L. Boon, S. Papadogiorgaki, M. Samiotaki, P. G. Foukas, A. Hatzioannou, T. Alissafi, M. L. Dustin, P. Verginis
This study identifies an immunosuppressive mechanism in the tumor microenvironment where SMA+ cancer-associated fibroblasts process and present tumor antigens via autophagy to form immunological synapses with Foxp3+ T regulatory cells, promoting tumor development.
bioRxiv · Dec 22, 2023 · PreprintCancer Biology