M. Santiago

Activation of cannabinoid CB2 receptors by (-)-cannabichromene but not (+)-cannabichromene

This study shows that (-)-cannabichromene activates CB2 receptors, while (+)-cannabichromene does not, and both activate TRPA1.

Histidine and its uptake are essential for the growth of Staphylococcus aureus at low pH

This study identifies genes essential for Staphylococcus aureus growth at low pH, highlighting histidine transport's role in maintaining intracellular pH.

Modulation of Recombinant Human T-type calcium channels by Δ9-tetrahydrocannabinolic acid in vitro

This study investigates the effects of THCA on T-type calcium channels in vitro, finding it modulates channel kinetics and voltage dependence without psychoactive effects.

Modulation of Human T-type Calcium Channels by Synthetic Cannabinoid Receptor Agonists in vitro

This study investigates how synthetic cannabinoid receptor agonists modulate human T-type calcium channels, finding potent inhibition and suggesting a potential mechanism for their toxicity.

Structure and reconstitution of a hydrolase complex that releases peptidoglycan from the membrane after polymerization

This paper identifies a hydrolase complex in Staphylococcus aureus that releases peptidoglycan from the membrane by cleaving nascent polymers, enabling their integration into the cell wall matrix.

High-throughput transposon sequencing highlights the cell wall as an important barrier for osmotic stress in methicillin resistant Staphylococcus aureus and underlines a tailored response to different osmotic stressors

This study uses TN-seq to analyze osmotic stress responses in S. aureus, identifying gene 957 as essential under salt stress and highlighting the role of cell wall crosslinking in osmotic resistance.

Differential activation of G protein-mediated signalling by synthetic cannabinoid receptor agonists

This study compares how synthetic cannabinoid receptor agonists activate Gs and Gi/o proteins, finding differences in their potency and rank order for cAMP stimulation and inhibition.