Author

M. Saponaro

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Aitsiankova· 1 shared A. Gambus· 1 shared A. J. Garvin· 1 shared A. K. Walker· 1 shared D. Poovathumkadavil· 1 shared E. Brown· 1 shared E. Petermann· 1 shared F. Dobbs· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCancer Biology

A. Aitsiankova

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2 papers

Recent·Most cited

USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.

H. L. Mackay, H. R. Stone, K. Ellis, G. Ronson, K. Starowicz, A. J. Garvin, P. Van Eijk, A. Aitsiankova, S. Vijayendran, J. Beesley, E. Petermann, E. Brown, R. M. Densham, S. H. Reed, F. Dobbs, , J. R. Morris

This study identifies USP50 as a ubiquitin-binding protein that regulates helicase and nuclease activities during DNA replication to prevent fork collapse and maintain genomic stability.

bioRxiv · Jan 10, 2024Cancer Biology

Ubiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication - transcription conflicts

S. Scaramuzza, M. Muste Sadurni, D. Poovathumkadavil, T. Natsume, P. Rojas, M. T. Kanemaki, M. Saponaro, A. Gambus

This study identifies TRAIP's role in preventing DNA damage during S-phase by resolving replication-transcription conflicts, leading to cell cycle arrest and senescence upon TRAIP depletion.

bioRxiv · Mar 23, 2022 · PreprintCell Biology