T. Natsume

Direct Relationship between Protein Expression and Progeny Yield of Herpes Simplex Virus 1 Unveils a Rate-limiting Step for Virus Production

This study identifies a direct relationship between viral protein expression and progeny yield in herpes simplex virus 1, revealing DNA cleavage/packaging as a rate-limiting step for virus production.

Characterising replisome disassembly in human cells

This study characterizes replisome disassembly in human cells, showing that Cullin2, LRR1, and p97 are required, and that replication stress occurs with inhibitor treatment.

Ubiquitin ligase TRAIP plays an essential role during the S-phase of unperturbed cell cycle in the resolution of DNA replication - transcription conflicts

This study identifies TRAIP's role in preventing DNA damage during S-phase by resolving replication-transcription conflicts, leading to cell cycle arrest and senescence upon TRAIP depletion.

MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells

This study shows that MCM10 compensates for c-Myc-induced DNA replication stress in breast cancer stem-like cells, promoting genome duplication and drug resistance.

NUDT21 links mitochondrial IPS-1 to RLR-containing stress granules and activates host antiviral defense

This study shows NUDT21 connects RLRs in stress granules to mitochondrial IPS-1, enabling antiviral defense by facilitating type I IFN induction.

Generation of conditional auxin-inducible degron (AID) cells and tight control of degron-fused proteins using the degradation inhibitor auxinole

This paper improves AID technology by introducing new plasmids and auxinole to control degron-fused protein degradation in human cells.

Optogenetic reconstitution reveals that Dynein-Dynactin-NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

This study uses optogenetic reconstitution to show that NuMA clusters Dynein-Dynactin to generate cortical spindle-pulling forces through multi-arm interactions.

Ki-67 and condensins support the integrity of mitotic chromosomes through distinct mechanisms

This study shows Ki-67 and condensins have independent yet cooperative roles in maintaining mitotic chromosome structure through distinct mechanisms.