A. K. Walker

USP50 suppresses alternative RecQ helicase use and deleterious DNA2 activity during replication.

This study identifies USP50 as a ubiquitin-binding protein that regulates helicase and nuclease activities during DNA replication to prevent fork collapse and maintain genomic stability.

S-adenosylmethionine synthases specify distinct H3K4me3 populations and gene expression patterns during heat stress

The paper identifies distinct roles of SAMS-1 and SAMS-4 in regulating H3K4me3 and gene expression during heat stress in C. elegans.

Stimulation of immunity-linked genes by membrane disruption is linked to Golgi function and the ARF-1 GTPase

The paper shows that immunity-linked genes are activated by both pathogen attack and lipid imbalances, linking these responses to Golgi function and ARF-1 GTPase disruption.

Neurodegenerative disease-associated protein aggregates are poor inducers of the heat shock response in neuronal-like cells

This study shows that neurodegenerative disease-associated protein aggregates fail to induce the heat shock response in neuronal-like cells, unlike non-pathogenic aggregation-prone proteins.

The deSUMOylase SENP2 coordinates homologous recombination and non-homologous end joining by independent mechanisms.

This study identifies SENP2 as a deSUMOylase that differentially regulates homologous recombination and non-homologous end joining through distinct mechanisms, impacting DSB repair and radioresistance.