Author

M. Saye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:deep learning· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Approach:mechanistic / dynamical model· 2 Assay:proteomics· 1 Approach:statistical model· 1 Organism:virus· 1

Frequent Co-Authors

C. A. Pereira· 5 shared C. Reigada· 5 shared E. Valera-Vera· 4 shared M. R. Miranda· 4 shared F. A. Digirolamo· 2 shared E. A. Valera-Vera· 1 shared F. Di Girolamo· 1 shared F. Galceran· 1 shared

Activity by Year

2019-2020 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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5 shared papersMicrobiology

C. A. Pereira

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Capsaicin inhibits arginine kinase and exerts anti-Trypanosoma cruzi activity

E. Valera-Vera, C. Reigada, M. Saye, F. A. Digirolamo, M. R. Miranda, C. A. Pereira

This study evaluates capsaicin's effect on TcAK activity and its trypanocidal activity against T. cruzi, finding it more effective than benznidazole.

bioRxiv · Jun 23, 2020Microbiology

Trypanocidal activity of the anthocyanidin delphinidin, a non-competitive inhibitor of arginine kinase

E. Valera-Vera, C. Reigada, M. Saye, F. A. Digirolamo, F. Galceran, M. R. Miranda, C. A. Pereira

The paper demonstrates that delphinidin inhibits TcAK in vitro with non-competitive kinetics and shows trypanocidal activity against T. cruzi.

bioRxiv · Jun 23, 2020Microbiology

Role of Trypanosoma cruzi nucleoside diphosphate kinase 1 in DNA-damage responses

C. Reigada, M. Saye, F. Di Girolamo, E. A. Valera-Vera, C. A. Pereira, M. R. Miranda

This study investigates the role of TcNDPK1 in DNA-damage responses in Trypanosoma cruzi, showing reduced mutation rates and increased resistance to genotoxic stress.

bioRxiv · Nov 4, 2019Microbiology

In silico identification of putative Trypanosoma cruzi enolase inhibitors

E. Valera-Vera, M. Saye, C. Reigada, M. R. Miranda, C. A. Pereira

The paper identifies potential inhibitors of Trypanosoma cruzi enolase using virtual screening, docking, and dynamics simulations, proposing etidronate as a candidate inhibitor.

bioRxiv · Jun 27, 2019Microbiology

Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069

M. Saye, L. Gauna, E. Valera-Vera, C. Reigada, M. Miranda, C. A. Pereira

This paper identifies crystal violet structural analogues with anti-Trypanosoma cruzi activity by inhibiting the proline transporter TcAAAP069 and shows synergistic effects with benznidazole.

bioRxiv · May 21, 2019Microbiology