Author

C. A. Pereira

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 3 Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:deep learning· 2 Approach:mechanistic / dynamical model· 2 Assay:proteomics· 2 Research Focus:metabolism & bioenergetics· 1 Organism:rat· 1

Frequent Co-Authors

C. Reigada· 5 shared M. Saye· 5 shared E. Valera-Vera· 4 shared M. R. Miranda· 4 shared F. A. Digirolamo· 2 shared E. A. Valera-Vera· 1 shared E. C. Carnio· 1 shared F. Di Girolamo· 1 shared

Activity by Year

2019-2020 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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5 shared papersMicrobiology

C. Reigada

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Capsaicin inhibits arginine kinase and exerts anti-Trypanosoma cruzi activity

E. Valera-Vera, C. Reigada, M. Saye, F. A. Digirolamo, M. R. Miranda, C. A. Pereira

This study evaluates capsaicin's effect on TcAK activity and its trypanocidal activity against T. cruzi, finding it more effective than benznidazole.

bioRxiv · Jun 23, 2020Microbiology

Trypanocidal activity of the anthocyanidin delphinidin, a non-competitive inhibitor of arginine kinase

E. Valera-Vera, C. Reigada, M. Saye, F. A. Digirolamo, F. Galceran, M. R. Miranda, C. A. Pereira

The paper demonstrates that delphinidin inhibits TcAK in vitro with non-competitive kinetics and shows trypanocidal activity against T. cruzi.

bioRxiv · Jun 23, 2020Microbiology

Role of Trypanosoma cruzi nucleoside diphosphate kinase 1 in DNA-damage responses

C. Reigada, M. Saye, F. Di Girolamo, E. A. Valera-Vera, C. A. Pereira, M. R. Miranda

This study investigates the role of TcNDPK1 in DNA-damage responses in Trypanosoma cruzi, showing reduced mutation rates and increased resistance to genotoxic stress.

bioRxiv · Nov 4, 2019Microbiology

Baroreceptor denervation reduces inflammatory status and worsens cardiovascular collapse during systemic inflammation

M. R. Amorim, J. L. de Deus, C. A. Pereira, L. E. V. da Silva, G. S. Borges, N. S. Ferreira, M. E. Batalhao, J. Antunes-Rodrigues, E. C. Carnio, R. C. Tostes, L. G. Branco

This study shows that baroreceptor denervation increases cytokine levels but worsens cardiovascular collapse during systemic inflammation in rats.

bioRxiv · Aug 29, 2019Immunology

In silico identification of putative Trypanosoma cruzi enolase inhibitors

E. Valera-Vera, M. Saye, C. Reigada, M. R. Miranda, C. A. Pereira

The paper identifies potential inhibitors of Trypanosoma cruzi enolase using virtual screening, docking, and dynamics simulations, proposing etidronate as a candidate inhibitor.

bioRxiv · Jun 27, 2019Microbiology

Crystal violet structural analogues identified by in silico drug repositioning present anti-Trypanosoma cruzi activity through inhibition of proline transporter TcAAAP069

M. Saye, L. Gauna, E. Valera-Vera, C. Reigada, M. Miranda, C. A. Pereira

This paper identifies crystal violet structural analogues with anti-Trypanosoma cruzi activity by inhibiting the proline transporter TcAAAP069 and shows synergistic effects with benznidazole.

bioRxiv · May 21, 2019Microbiology