A cell-permeant nanobody-based degrader that induces fetal hemoglobin
F. Shen, G. Zheng, M. Setegne, K. Tenglin, M. Izada, H. Xie, L. Zhai, S. H. Orkin, L. M. K. Dassama
A cell-permeant nanobody-based degrader depletes BCL11A in erythroid cells, inducing fetal hemoglobin expression.
bioRxiv · Jun 7, 2022Biochemistry