F. Shen

A PTER-dependent pathway of taurine metabolism linked to energy balance

This study identifies PTER as the taurine N-acetyltransferase/hydrolase, showing its role in regulating N-acetyltaurine levels and linking it to energy balance and metabolic phenotypes.

A cell-permeant nanobody-based degrader that induces fetal hemoglobin

A cell-permeant nanobody-based degrader depletes BCL11A in erythroid cells, inducing fetal hemoglobin expression.

Miniature inverted-repeat transposable elements drive rapid microRNA diversification in angiosperms

The paper identifies MITEs as a source of new miRNAs in angiosperms, showing they rapidly diversify miRNA repertoires through transposition and transcription.

Contrasting patterns and co-occurrence network of soil bacterial and fungal community along depth profiles in cold temperate montane forests of China

This study examines soil bacterial and fungal community patterns and co-occurrence networks along depth and altitude gradients in cold-temperate forests, finding altitude has a stronger impact than depth.

Base Pairing and Functional Insights into N3-methylcytidine (m3C) in RNA

This study investigates the effects of N3-methylcytidine (m3C) modification on RNA base pairing and reverse transcription, showing its impact on stability, discrimination, and mutation induction.

Exosomes exploit the virus entry machinery and pathway to transmit IFN-α-induced antiviral activity.

This study identifies TIM-1 and endocytic pathways as key mediators of exosome entry and cargo delivery for IFN-α-induced antiviral activity transfer from macrophages to hepatocytes.

5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular Carcinoma

This study develops a 5-hydroxymethylcytosine (5hmC) diagnostic model from circulating cell-free DNA to detect hepatocellular carcinoma with high accuracy and prognostic value.

Comparison of village dog and wolf genomes highlights the pivotal role of the neural crest in dog domestication

This study compares village dog and wolf genomes to identify domestication-related genes, finding neural crest-related genes are pivotal in dog domestication.