G. Zheng

A step-emulsion based digital-RPA for Pathogenic bacteria detection

This paper develops a step-emulsion microfluidic device combined with digital-RPA for rapid, sensitive, and quantitative detection of Vibrio parahaemolyticus with a detection limit of 10 CFU/L.

PROTAC-mediated dual degradation of BCL-xL and BCL-2 is a highly effective therapeutic strategy in small-cell lung cancer

This paper evaluates a dual BCL-xL/BCL-2 degrader, 753b, showing it effectively reduces tumor viability and growth in SCLC models while avoiding platelet toxicity seen with navitoclax.

Multifunctional biomimetic porphyrin-lipid nanoparticles - novel nanoscale theranostics for atherosclerotic cardiovascular disease

This paper develops Por-HDL-NPs for atherosclerosis theranostics, showing they reduce inflammation, promote cholesterol efflux, and visualize plaques via imaging.

Unleashing the Power of NR4A1 Degradation as a Novel Strategy for Cancer Immunotherapy

This paper develops a PROTAC molecule (NR-V04) that degrades NR4A1, leading to tumor inhibition and immune modulation in melanoma.

Co-targeting BCL-XL and MCL-1 with DT2216 and AZD8055 synergistically inhibits small-cell lung cancer growth without causing on-target toxicities in mice

Targeted degradation of microtubule-associated protein tau using an engineered nanobody-E3 ubiquitin ligase adapter fusion

This paper demonstrates that an engineered nanobody-E3 ubiquitin ligase adapter fusion can effectively degrade tau in mouse neurons by leveraging nuclear proteasomal activity.

A cell-permeant nanobody-based degrader that induces fetal hemoglobin

A cell-permeant nanobody-based degrader depletes BCL11A in erythroid cells, inducing fetal hemoglobin expression.

A Microfluidic Chip for LAMP-based Multiplex Detection of Pathogen

The paper develops a microfluidic chip for LAMP-based multiplex detection of three bacterial pathogens and reports LOD values for Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa.

Microfluidic chemostatic bioreactor for high-throughput screening and sustainable co-harvesting of biomass and biodiesel in microalgae

This paper develops a microfluidic chemostatic bioreactor for high-throughput screening of microalgal growth and lipid production, achieving higher throughput and efficiency compared to traditional methods.

A microfluidic droplet array demonstrating high-throughput screening in individual lipid-producing microalgae

The paper develops a microfluidic droplet array for high-throughput screening of lipid-producing microalgae, enabling real-time monitoring and identification of individual cells under different conditions.

An interactive viral genome evolution network analysis system enabling rapid large-scale molecular tracing of SARS-CoV-2

This paper introduces VENAS, a system for analyzing SARS-CoV-2 genome evolution networks, enabling rapid processing and visualization of large datasets to trace viral mutations and transmission.

Piperlongumine (PL) conjugates induce targeted protein degradation

The paper identifies piperlongumine as a covalent E3 ligase recruiter that, when conjugated with CDK9 inhibitors, induces targeted protein degradation of CDK9 and EML4-ALK fusion oncoprotein.

High-throughput functional characterization of visceral afferents by optical recordings from thoracolumbar and lumbosacral dorsal root ganglions

The paper develops a cost-effective microscopy system for high-throughput optical recordings of visceral afferent activity in mouse dorsal root ganglia.

Role of RgsA in oxidative stress resistance in Pseudomonas aeruginosa

This study shows that deletion of RgsA in Pseudomonas aeruginosa reduces growth and oxidative stress resistance in both planktonic and biofilm states.

Direct control of shell regeneration by the mantle tissue in the pearl oyster Pinctada fucata via accelerating CaCO3 nucleation

This study shows that mantle tissue retraction and dislocation in Pinctada fucata directly control shell regeneration by accelerating CaCO3 nucleation through increased shell matrix protein expression.