Insect hormone PTTH regulates lifespan through temporal and spatial activation of NF-κB signaling during metamorphosis
P. Kang, P. Liu, J. Kim, A. Kumar, M. Bolton, W. A. Murzyn, Z. J. Anderson, L. N. Frank, N. Kavlock, E. Hoffman, C. C. Martin, M. K. Dorneich-Hayes, T. Miao, M. Shimell, W. Chen, , H. Bai
This study shows that PTTH loss-of-function in Drosophila extends lifespan by repressing NF-κB signaling in oenocytes during metamorphosis.
bioRxiv · Sep 30, 2023 · PreprintPhysiology