H. Bai

A Comprehensive Model of Blood Flow Restriction in the Post-surgical Rat

This paper introduces a comprehensive protocol for implementing blood flow restriction exercise in awake rats following ACL-R to study its effects on muscle growth and atrophy.

DERIVATION OF ELEPHANT INDUCED PLURIPOTENT STEM CELLS

This paper reports the first derivation of elephant induced pluripotent stem cells (emiPSCs) using a modified reprogramming protocol that inhibits TP53 expansion genes.

Starvation resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity

The paper identifies FATP2 as a conserved target for preventing starvation-induced liver atrophy by reducing fatty acid uptake in cavefish and other species.

Serine hydroxymethyl transferase is a binding target of caprylic acid: Uncovering a novel molecular target for a herbicide and for producing caprylic acid-tolerant crops

This study identifies serine hydroxymethyl transferase (SHMT) as a binding target of caprylic acid, showing its role in herbicidal activity and potential for developing tolerant crops.

Contemporary HIV-1 consensus Env with redesigned hypervariable loops promote antibody binding

The paper redesigns hypervariable loops in HIV-1 Env consensus sequences to enhance antibody binding and improve vaccine antigen design.

Insect hormone PTTH regulates lifespan through temporal and spatial activation of NF-κB signaling during metamorphosis

This study shows that PTTH loss-of-function in Drosophila extends lifespan by repressing NF-κB signaling in oenocytes during metamorphosis.

Proteomic analysis revealed the function of PoElp3 in development, pathogenicity, and autophagy through the tRNA-mediated translation efficiency in the rice blast fungus

Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy

This paper develops a method to rapidly prototype thermoplastic microfluidic devices for 3D cell culture by creating regional hydrophilicity discrepancies, enabling dynamic cell culture and drug screening.

De novo design of highly selective miniprotein inhibitors of integrins αvβ6 and αvβ8

This paper designs highly selective miniprotein inhibitors for integrins αvβ6 and αvβ8 with picomolar affinity and therapeutic potential in a mouse fibrosis model.

Synergistic effects of multiple pesticides on the flight ability of honey bees (Apis cerana F.)

This study shows that combinations of imidacloprid, chlorpyrifos, and glyphosate synergistically reduce flight ability in honey bees, while individual pesticides do not.

Progressive Senescence Programs Induce Intrinsic Vulnerability to Aging-related Breast Cancer

This study identifies progressive senescence programs in mammary cells that increase vulnerability to aging-related breast cancer and presents a drug to mitigate this risk.

De novo design of modular peptide binding proteins by superhelical matching

This paper introduces a method to design modular peptide binding proteins that bind repeating peptide sequences with high specificity and affinity.

Robust deep learning based protein sequence design using ProteinMPNN

A deep learning method for protein sequence design shows high performance in both simulations and experiments, applicable to various design challenges.

Genomic insights into the adaptive and convergent evolution of Leuciscus waleckii inhabiting extremely alkaline environments

This study identifies genomic adaptations in Leuciscus waleckii to extreme alkaline environments through genome assembly and population analysis.

Quality Control Framework of TCM Preparations based on Multi-type Fingerprints using a Source Proportion Estimation Model

This paper proposes a quality control framework for TCM preparations using multi-type fingerprints and a source proportion estimation model to evaluate batch consistency and manufacturer differences.

Harringtonine has the effects of double blocking SARS-CoV-2 membrane fusion

This study shows Harringtonine inhibits SARS-CoV-2 membrane fusion by targeting both the viral S protein and host TMPRSS2, effectively blocking infection in delta and Omicron variants.

Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity

This paper introduces self-assembling short duplex RNAs that induce interferon production and inhibit multiple respiratory viruses.

Bioimage postprocessing based on discrete wavelet transform and Lucy-Richardson deconvolution methods

This paper improves image resolution and signal-to-noise ratio in live cell imaging using a combination of discrete wavelet transform and Lucy-Richardson deconvolution.

Survival mechanism of a novel marine multistress-tolerant Meyerozyma guilliermondii GXDK6 under high NaCl stress as revealed by integrative omics analysis

This study identifies the survival mechanism of Meyerozyma guilliermondii GXDK6 under high NaCl stress using integrative omics analysis, revealing key genes and pathways involved in salt tolerance.

Mechanical control of innate immune responses against viral infection revealed in a human Lung Alveolus Chip

This study shows that mechanical breathing motions suppress viral replication by enhancing innate immune responses in a human Lung Alveolus Chip model.

Lamp1 mediates lipid transport, but is dispensable for autophagy in Drosophila

This study shows that Drosophila Lamp1 is not required for autophagy but is involved in lipid transport and metabolism, leading to elevated sterols and diacylglycerols in mutants.

Plant trait heterosis is quantitatively associated with expression heterosis of plastid ribosomal proteins

This study identifies chloroplast ribosomal protein expression heterosis as a quantitative predictor of plant height heterosis in maize hybrids.

Morphologic Classification and Automatic Diagnosis of Bacterial Vaginosisby Deep Neural Networks

This paper develops CNN models to automatically classify Nugent scores from vaginal microscopy images, achieving higher accuracy than human experts.

A SARS-CoV-2 vaccine candidate would likely match all currently circulating strains

The paper analyzes SARS-CoV-2 sequence diversity and finds limited variation in the Spike protein, suggesting a single vaccine could be effective against current strains.

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein

The paper reports the high-resolution structure of the SARS-CoV-2 Spike RBD and identifies a conserved epitope accessible in open conformations, which is targeted by cross-reactive antibodies.

Discovery of influenza drug resistance mutations and host therapeutic targets using a human airway chip

The paper uses a human airway chip to discover influenza drug resistance mutations and identify host therapeutic targets for antiviral drugs.

Impaired peroxisomal import in Drosophila hepatocyte-like cells induces cardiac dysfunction through the pro-inflammatory cytokine Upd3

This study shows that impaired peroxisomal import in Drosophila oenocytes increases Upd3, causing cardiac arrhythmia, and that restoring peroxisomal import prevents this effect.