Transgenic pyrimethamine-resistant P. falciparum reveals transmission blocking potency of P218, a novel antifolate
N. Posayapisit, J. Pengon, P. Prommana, M. Shoram, Y. Yuthavong, C. Uthaipibull, S. Kamchonwongpaisan, N. Jupatanakul
This study develops transgenic P. falciparum resistant to pyrimethamine but capable of gametocyte production and shows that P218 inhibits exflagellation more effectively than its erythrocytic stage effect.
bioRxiv · Sep 6, 2020Microbiology