M. Shukla

Data Imbalance in Drug Response Prediction - Multi-Objective Optimization Approach in Deep Learning Setting

This paper addresses data imbalance in drug response prediction by introducing a multi-objective optimization approach using a custom loss function to improve model performance.

MAP Kinase and mammalian target of rapamycin are main pathways of gallbladder carcinogenesis: Results from bioinformatic analysis of Next Generation Sequencing data from a hospital-based cohort.

The paper identifies MAP kinase and mTOR pathways as key drivers of gallbladder carcinogenesis through bioinformatic analysis of NGS data from a hospital-based cohort.

Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation

This paper investigates the effect of inhibiting the H3K27 demethylase UTX on HIV-1 latency, finding that it enhances epigenetic silencing but does not provide permanent suppression.