Author

T. Brettin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:metagenomics· 1 Approach:optimal transport· 1

Frequent Co-Authors

A. Brace· 1 shared A. Clyde· 1 shared A. Kovalevsky· 1 shared A. Merzky· 1 shared A. Partin· 1 shared A. Ramanathan· 1 shared A. Trifan· 1 shared B. Blaiszik· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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1 shared paperBiophysics

A. Brace

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Data Imbalance in Drug Response Prediction - Multi-Objective Optimization Approach in Deep Learning Setting

O. Narykov, Y. Zhu, T. Brettin, Y. A. Evrard, A. Partin, F. Xia, M. Shukla, P. Vasanthakumari, J. H. Doroshow, R. L. Stevens

This paper addresses data imbalance in drug response prediction by introducing a multi-objective optimization approach using a custom loss function to improve model performance.

Briefings in Bioinformatics · Apr 3, 2025Peer-reviewedCancer Biology

High Throughput Virtual Screening and Validation of a SARS-CoV-2 Main Protease Non-Covalent Inhibitor

A. Clyde, S. Galanie, D. W. Kneller, H. Ma, Y. Babuji, B. Blaiszik, A. Brace, T. Brettin, K. Chard, R. Chard, L. Coates, I. Foster, D. Hauner, V. Kertesz, N. Kumar, , R. Stevens

This paper identifies a novel non-covalent inhibitor of SARS-CoV-2 main protease through high throughput virtual screening, validated by biochemical assays, X-ray crystallography, and molecular dynamics simulations.

bioRxiv · Mar 27, 2021 · PreprintBiophysics

Discovery and whole genome sequencing of a human clinical isolate of the novel species Klebsiella quasivariicola sp. nov.

S. W. Long, S. E. Linson, M. O. Saavedra, C. Cantu, J. J. Davis, T. Brettin, R. J. Olsen

The paper discovers a new Klebsiella species, K. quasivariicola, through whole genome sequencing of a clinical isolate phylogenetically distinct from known species.

bioRxiv · Aug 15, 2017Microbiology