Exogenous DNA upregulates DUOX2 expression and function in human pancreatic cancer cells by activating the cGAS-STING signaling pathway
S. L. Wang, Y. Wu, M. Konate…·J. H. Doroshow
This study shows exogenous DNA activates the cGAS-STING pathway in pancreatic cancer cells, increasing DUOX2 expression and H2O2 production, which may promote an oxidative microenvironment.