Author

J. Karn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. Dobrowolski· 3 shared K. Nguyen· 2 shared A. D. Badley· 1 shared A. Herschhorn· 1 shared A. Pagliuzza· 1 shared A. T. Haase· 1 shared B. G. LUTTGE· 1 shared B. Howell· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersImmunology

C. Dobrowolski

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Reduction of the HIV-1 reservoir in T cells from persons with HIV-1 on suppressive antiretroviral therapy using expanded natural killer cells ex vivo

M. A. Checkley Luttge, B. G. LUTTGE, C. Dobrowolski, D. N. Wald, D. McMahon, G. Haidar, M. D. Sobolewski, P. N. Enick, J. Cyktor, J. W. Mellors, J. Karn

This study shows that expanded natural killer cells can reduce HIV-1 reservoirs in treated patients when combined with latency-reversing agents and broadly neutralizing antibodies.

bioRxiv · Sep 5, 2022 · PreprintImmunology

Detecting sources of immune activation and viral rebound in HIV infection

S. Wietgrefe, L. Duan, J. Anderson, G. Marques, M. Sanders, N. W. Cummins, A. D. Badley, C. Dobrowolski, J. Karn, A. Pagliuzza, N. Chomont, G. Sannier, M. Dube, D. E. Kaufmann, P. Zuck, , A. T. Haase

The paper compares assays for detecting HIV-producing cells and p24 during ART to identify sources of immune activation and viral rebound.

bioRxiv · Jun 8, 2022Immunology

The Nerve Growth Factor IB-like Receptor Nurr1 (NR4A2) recruits CoREST transcription repressor complexes to silence HIV following proviral reactivation in microglial cells

F. Ye, D. Alvarez-Carbonell, K. Nguyen, S. Valadkhan, K. Leskov, Y. Garcia-Mesa, S. Sreeram, J. Karn

This study shows that Nurr1 agonists enhance HIV silencing in microglial cells by recruiting CoREST repressor complexes to the HIV promoter, promoting latency and reducing neuroinflammation.

bioRxiv · Nov 16, 2021 · PreprintMicrobiology

Inhibition of the H3K27 demethylase UTX enhances the epigenetic silencing of HIV proviruses and induces HIV-1 DNA hypermethylation but fails to permanently block HIV reactivation

K. Nguyen, C. Dobrowolski, M. Shukla, W.-K. Cho, J. Karn

This paper investigates the effect of inhibiting the H3K27 demethylase UTX on HIV-1 latency, finding that it enhances epigenetic silencing but does not provide permanent suppression.

bioRxiv · Aug 2, 2021Microbiology