Tankyrase inhibition sensitizes cells to CDK4 blockade
M. Foronda, Y. Tarumoto, E. M. Schatoff, B. I. Leach, B. J. Diaz, S. Goswami, M. Shusterman, C. R. Vakoc, L. Dow
This study identifies that combining TNKS inhibition with CDK4 loss drives G1 cell cycle arrest and senescence in epithelial cancers.
bioRxiv · Jun 21, 2019Cancer Biology