Author

B. I. Leach

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:biophysical modeling· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:protein structure· 1

Frequent Co-Authors

J. A. Ferguson· 2 shared X. Sun· 2 shared B. J. Diaz· 1 shared C. R. Vakoc· 1 shared D. Oyen· 1 shared E. M. Schatoff· 1 shared G. J. Morgan· 1 shared G. Kroon· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersBiophysics

J. A. Ferguson

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3 papers

Recent·Most cited

Characterization of an amyloidogenic intermediate of transthyretin by NMR relaxation dispersion

B. I. Leach, J. A. Ferguson, G. J. Morgan, X. Sun, G. Kroon, D. Oyen, J. Dyson, P. Wright

This study uses NMR relaxation dispersion to characterize the structural dynamics of an amyloidogenic intermediate of transthyretin, revealing conformational fluctuations that promote amyloid formation.

bioRxiv · Feb 16, 2024Biophysics

Probing the dissociation pathway of a kinetically labile transthyretin mutant

X. Sun, J. A. Ferguson, B. I. Leach, R. L. Stanfield, H. J. Dyson, P. E. Wright

This study investigates the dissociation pathway of a kinetically labile transthyretin mutant using NMR and MD simulations to quantify the energy landscape at neutral pH.

bioRxiv · Jun 21, 2023Biophysics

Tankyrase inhibition sensitizes cells to CDK4 blockade

M. Foronda, Y. Tarumoto, E. M. Schatoff, B. I. Leach, B. J. Diaz, S. Goswami, M. Shusterman, C. R. Vakoc, L. Dow

This study identifies that combining TNKS inhibition with CDK4 loss drives G1 cell cycle arrest and senescence in epithelial cancers.

bioRxiv · Jun 21, 2019Cancer Biology