Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity
D. M. Foulkes, K. McLean, M. Sloniecka, D. Byrne, A. S. Haneef, C. Winstanley, N. Berry, D. Fernig, S. B. Kaye
This study evaluates the effects of fluoroquinolones and aminoglycosides on P. aeruginosa T3SS expression and cytotoxicity in corneal epithelial cell models, finding tobramycin inhibits T3SS and cytotoxicity while fluoroquinolones upregulate T3SS and enhance cytotoxicity.
bioRxiv · Oct 11, 2021Biochemistry