Author

D. M. Foulkes

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

C. Winstanley· 3 shared D. Fernig· 3 shared K. McLean· 3 shared N. Berry· 3 shared S. B. Kaye· 3 shared A. Haneef· 1 shared A. Hermann· 1 shared A. S. Haneef· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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3 shared papersBiochemistry

C. Winstanley

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Author profile →

3 papers

Recent·Most cited

A phospholipase assay screen identifies synergistic inhibitors of the P. aeruginosa toxin ExoU

D. M. Foulkes, K. McLean, A. Hermann, J. Johnson, C. Winstanley, N. Berry, D. Fernig, S. B. Kaye

This study identifies synergistic inhibitors of P. aeruginosa ExoU through a phospholipase assay screen, showing reduced cytotoxicity in vitro and in corneal assays.

bioRxiv · Feb 21, 2022 · PreprintBiochemistry

Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity

D. M. Foulkes, K. McLean, M. Sloniecka, D. Byrne, A. S. Haneef, C. Winstanley, N. Berry, D. Fernig, S. B. Kaye

This study evaluates the effects of fluoroquinolones and aminoglycosides on P. aeruginosa T3SS expression and cytotoxicity in corneal epithelial cell models, finding tobramycin inhibits T3SS and cytotoxicity while fluoroquinolones upregulate T3SS and enhance cytotoxicity.

bioRxiv · Oct 11, 2021Biochemistry

Evaluation of ExoU inhibitors in a Pseudomonas aeruginosa scratch infection assay

D. M. Foulkes, K. McLean, J. Harris, A. Haneef, D. Fernig, C. Winstanley, N. Berry, S. B. Kaye

This study evaluates ExoU inhibitors in a Pseudomonas aeruginosa scratch infection model, showing their effectiveness in reducing cytotoxicity when combined with antimicrobials.

bioRxiv · Jun 24, 2020 · PreprintBiochemistry