D. Byrne

Cold temperature induces a TRPM8-independent calcium release from the endoplasmic reticulum in human platelets

This study shows cold temperature activates human platelets via TRPM8-dependent and -independent mechanisms, with TRPM8 involved in early activation and ER calcium release driving later responses.

A Peroxiredoxin-P38 MAPK scaffold increases MAPK activity by MAP3K-independent mechanisms

This paper shows that a Peroxiredoxin-P38 MAPK fusion protein hyperactivates P38 MAPK in yeast and human cells without requiring H2O2-sensing cysteines, suggesting a novel scaffold-based signaling mechanism.

Impact of fluoroquinolones and aminoglycosides on P. aeruginosa virulence factor production and cytotoxicity

This study evaluates the effects of fluoroquinolones and aminoglycosides on P. aeruginosa T3SS expression and cytotoxicity in corneal epithelial cell models, finding tobramycin inhibits T3SS and cytotoxicity while fluoroquinolones upregulate T3SS and enhance cytotoxicity.

Characterization of Rose rosette virus and development of reverse genetic system for studying virus accumulation and movement in whole plants.

This paper characterizes Rose rosette virus (RRV) and develops a reverse genetic system to study its replication, movement, and protein functions in plants.

HetL provides immunity to HetR against PatS inhibition, and promotes pattern formation in the cyanobacterium Nostoc PCC 7120

The paper shows HetL provides immunity to HetR against PatS inhibition, enabling heterocyst differentiation in Nostoc PCC 7120 under nitrogen starvation.

Covalent Aurora A regulation by the metabolic integrator coenzyme A

This study identifies a novel covalent inhibition mechanism of Aurora A kinase by coenzyme A, showing its regulation under oxidative stress and impact on meiotic spindle formation.

New tools for evaluating protein tyrosine sulphation: Tyrosyl Protein Sulphotransferases (TPSTs) are novel targets for RAF protein kinase inhibitors

The paper develops a non-radioactive assay to quantify tyrosine sulphation by TPST1 and TPST2 and identifies RAF kinase inhibitors as potential TPST inhibitors.

The nucleoid as a scaffold for the assembly of bacterial signaling complexes

The paper shows that FrzCD chemoreceptors bind the bacterial nucleoid non-sequence-specifically, forming distributed clusters that enable cooperative signaling.