Author

M. Solvay

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

J. Zhu· 2 shared A. Gollowitzer· 1 shared A. Kowar· 1 shared A. Leytens· 1 shared A. M. Heberle· 1 shared A. Reintjes· 1 shared A. Sadik· 1 shared A. van Pijkeren· 1 shared

Activity by Year

2023-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersCell Biology

J. Zhu

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Author profile →

2 papers

Recent·Most cited

Tryptophan depletion sensitizes the AHR pathway by increasing AHR expression and GCN2/LAT1-mediated kynurenine uptake, and potentiates induction of regulatory T lymphocytes

M. Solvay, P. Pfander, S. Klaessens, L. Pilotte, V. Stroobant, J. Lamy, S. Naulaerts, Q. Spillier, R. Frederick, E. De Plaen, C. Sers, C. A. Opitz, B. J. Van den Eynde, J. Zhu

This study shows that tryptophan depletion increases AHR expression and kynurenine uptake, enhancing AHR activation and promoting regulatory T cell differentiation.

bioRxiv · Jan 16, 2023Cell Biology

The MTORC1-AHR pathway sustains translation and autophagy in tumours under tryptophan stress

P. Holfelder, L. Hensen, M. T. Prentzell, P. Razquin Navas, M. Solvay, A. Sadik, D. Sayeeram, U. Rehbein, T. Bausbacher, A.-S. Egger, L. Regin, A. M. Heberle, S. Seifert, A. Leytens, A. Kowar, , S. Harder

This study identifies the MTORC1-AHR pathway as a mechanism sustaining translation and autophagy in tumors under tryptophan stress by enhancing AHR activity and autophagy regulators.

bioRxiv · Jan 16, 2023 · PreprintBiochemistry