Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors.
L. Ding, L. Sun, M. T. Bu, Y. Zhang, L. N. Scott, R. M. Prins, M. Su, M. G. Lechner, W. HUGO
This study identifies that clonally diverse CXCR5+ B cells enhance IFNγ pathway activity and CD8 T cell responses, leading to durable ICI therapy outcomes in melanoma.
Frontiers in Immunology · Jun 26, 2023Peer-reviewedCancer Biology