Author

L. N. Scott

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

M. G. Lechner· 2 shared W. HUGO· 2 shared A. Drakaki· 1 shared A. Ribas· 1 shared A. T. Hoang· 1 shared A. Y. Patel· 1 shared B. Alkner· 1 shared C. S. Fry· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

M. G. Lechner

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The 24-Hour Time Course of Integrated Molecular Responses to Resistance Exercise in Human Skeletal Muscle Implicates MYC as a Hypertrophic Regulator That is Sufficient for Growth

S. Edman, R. G. Jones, P. R. Jannig, R. Fernandez-Gonzalo, J. Norrbom, N. T. Thomas, S. Khadgi, P. J. Koopmans, F. Morena, C. S. Peterson, L. N. Scott, N. P. Greene, V. C. Figueiredo, C. S. Fry, L. Zhengye, , F. von Walden

This study maps the 24-hour molecular response to resistance exercise in human muscle, identifying MYC as a key regulator of hypertrophy and mRNA levels.

bioRxiv · Mar 26, 2024 · PreprintCell Biology

Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors.

L. Ding, L. Sun, M. T. Bu, Y. Zhang, L. N. Scott, R. M. Prins, M. Su, M. G. Lechner, W. HUGO

This study identifies that clonally diverse CXCR5+ B cells enhance IFNγ pathway activity and CD8 T cell responses, leading to durable ICI therapy outcomes in melanoma.

Frontiers in Immunology · Jun 26, 2023Peer-reviewedCancer Biology

Clonally-Expanded, Thyrotoxic Autoimmune Mediator CD8+ T cells Driven by IL21 Contribute to Checkpoint Inhibitor Thyroiditis

M. G. Lechner, Z. Zhou, A. T. Hoang, N. Huang, J. Ortega, L. N. Scott, H.-C. Chen, A. Y. Patel, R. Y. Tafti, K. Kim, W. Hugo, P. Famini, A. Drakaki, A. Ribas, T. E. Angell, M. A. Su

The paper identifies clonally expanded CD8+ T cells driven by IL21 in ICI-thyroiditis using scRNA-seq and validates their role in thyroid inflammation.

bioRxiv · Dec 18, 2022 · PreprintImmunology