Author

W. Hugo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cancer Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

M. G. Lechner· 4 shared H.-C. Chen· 3 shared A. Drakaki· 2 shared A. Ribas· 2 shared A. T. Hoang· 2 shared A. Y. Patel· 2 shared L. N. Scott· 2 shared M. A. Su· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersImmunology

M. G. Lechner

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

A pathologically expanded, clonal lineage of IL-21 producing CD4+ T cells drives Inflammatory neuropathy

M. Seyedsadr, M. Bang, E. McCarthy, S. Zhang, H.-C. Chen, M. Mohebbi, W. HUGO, J. K. Whitmire, M. G. Lechner, M. Su

The paper identifies IL-21-expressing CD4+ T cells in an inflammatory neuropathy mouse model and shows their role in neuropathy development through clonal expansion and CXCR6-mediated infiltration.

bioRxiv · Jan 7, 2024Immunology

Antigen presentation by clonally diverse CXCR5+ B cells to CD4 and CD8 T cells is associated with durable response to immune checkpoint inhibitors.

L. Ding, L. Sun, M. T. Bu, Y. Zhang, L. N. Scott, R. M. Prins, M. Su, M. G. Lechner, W. HUGO

This study identifies that clonally diverse CXCR5+ B cells enhance IFNγ pathway activity and CD8 T cell responses, leading to durable ICI therapy outcomes in melanoma.

Frontiers in Immunology · Jun 26, 2023Peer-reviewedCancer Biology

Clonally-Expanded, Thyrotoxic Autoimmune Mediator CD8+ T cells Driven by IL21 Contribute to Checkpoint Inhibitor Thyroiditis

M. G. Lechner, Z. Zhou, A. T. Hoang, N. Huang, J. Ortega, L. N. Scott, H.-C. Chen, A. Y. Patel, R. Y. Tafti, K. Kim, W. Hugo, P. Famini, A. Drakaki, A. Ribas, T. E. Angell, M. A. Su

The paper identifies clonally expanded CD8+ T cells driven by IL21 in ICI-thyroiditis using scRNA-seq and validates their role in thyroid inflammation.

bioRxiv · Dec 18, 2022 · PreprintImmunology

Inhibition of the IL-17A axis Protects against Immune-related Adverse Events while Supporting Checkpoint Inhibitor Anti-tumor Efficacy

M. G. Lechner, A. Y. Patel, W. Hugo, T. E. Angell, M. I. Cheng, M. S. Pioso, A. T. Hoang, N. Yakobian, E. C. McCarthy, H.-C. Chen, E. D. Rodriguez, L. Guo, M. Astourian, A. Drakaki, P. Famini, , M. A. Su

This study shows that inhibiting the IL-17A axis reduces immune-related adverse events in checkpoint inhibitor-treated mice without affecting anti-tumor efficacy.

bioRxiv · Jan 19, 2022Immunology

Multi-model preclinical platform predicts clinical response of melanoma to immunotherapy

E. Perez-Guijarro, H. H. Yang, R. E. Araya, R. El Meskini, H. T. Michael, S. K. Vodnala, K. L. Marie, C. Graff-Cherry, S. Chin, A. J. Iacovelli, A. Kulaga, A. Fon, A. M. Michalowski, W. Hugo, R. S. Lo, , G. Merlino

The paper develops a preclinical platform using syngeneic mouse models to predict melanoma patient response to immunotherapy and identifies a melanocytic plasticity signature linked to treatment outcomes.

bioRxiv · Aug 6, 2019 · PreprintCancer Biology