ZNF416 is a pivotal transcriptional regulator of fibroblast mechano-activation
D. L. Jones, J. A. Meridew, M. T. Ducharme, K. L. Lydon, K. M. Choi, N. Caporarello, Q. Tan, P. A. Link, A. M. Diaz Espinosa, Y. Xiong, J.-H. Lee, Z. Ye, H. Yan, T. Ordog, G. Ligresti, , D. J. Tschumperlin
This study identifies ZNF416 as a key transcriptional regulator that mediates fibroblast responses to matrix stiffness through chromatin accessibility and gene expression changes.
bioRxiv · Jul 23, 2020Cell Biology