Hsp90 provides a platform for kinase dephosphorylation by PP5
M. Jaime-Garza, C. A. Nowotny, D. Coutandin, F. Wang, M. Tabios, D. A. Agard
The paper shows Hsp90 facilitates PP5-mediated dephosphorylation of CRaf by scaffolding PP5's interaction with Hsp90-bound CRaf, revealing a new role for Hsp90 in post-translational modification of client kinases.
bioRxiv · Sep 2, 2022 · PreprintBiophysics