Integrated Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of Acute Graft-versus-Host-Disease
J. K. Lohmeyer, T. Hirai, M. Turkoz, S. Buhler, T. L. Ramos, N. Koehler, J. Baker, X. Ji, J. Villard, Y. Chalandon, F. Simonetta, R. S. Negrin
This study identifies how regulatory T cells suppress acute graft-versus-host disease by modulating conventional T cell transcriptomes and metabolism without affecting graft-versus-tumor activity.
bioRxiv · Jul 26, 2022 · PreprintImmunology