R. S. Negrin

Extracellular release of damaged mitochondria induced by pre-hematopoietic stem cell transplant conditioning exacerbates graft-versus-host disease

This study shows that conditioning before hematopoietic stem cell transplant releases damaged mitochondria, which activate host APCs and worsen GVHD.

Single-cell Transcriptomics Reveal Different Maturation Stages and Sublineages Commitment of Human Thymic Invariant Natural Killer T cells

This study uses single-cell RNA sequencing to identify maturation stages and sublineage commitment in human thymic iNKT cells, revealing two distinct clusters with immature and mature profiles.

Integrated Analysis of T cell Repertoire and Transcriptome Identifies Mechanisms of Regulatory T cell (Treg) Suppression of Acute Graft-versus-Host-Disease

This study identifies how regulatory T cells suppress acute graft-versus-host disease by modulating conventional T cell transcriptomes and metabolism without affecting graft-versus-tumor activity.

Multi-parameter optical imaging of immune cell activity in chimeric antigen receptor T-cell and checkpoint blockade therapies

The paper develops a small molecule for imaging immune cell activity in cancer immunotherapies and demonstrates its utility in predicting treatment outcomes.

Allogeneic CAR-invariant Natural Killer T Cells Exert Potent Antitumor Effects Through Host CD8 T cell Cross-Priming

This study shows allogeneic CAR-iNKT cells effectively combat tumors in mice by directly attacking cancer cells and boosting host CD8 T cell responses, even across major MHC barriers.