M. V. Nachury

The ancestral ESCRT protein TOM1L2 selects ubiquitinated cargoes for retrieval from cilia

The paper identifies TOM1L2 as a ciliary trafficking factor that recognizes K63-linked ubiquitin chains to retrieve ubiquitinated GPCRs from cilia.

Time-resolved proteomic profiling of the ciliary Hedgehog response reveals that GPR161 and PKA undergo regulated co-exit from cilia

The paper uses proximity labeling and mass spectrometry to profile ciliary proteome changes during Hedgehog signaling, identifying new proteins involved in ciliary exit and signaling regulation.

Lysine63-linked ubiquitin chains earmark GPCRs for BBSome-mediated removal from cilia

This study shows that K63-linked ubiquitin chains tag GPCRs for BBSome-mediated removal from cilia, requiring β-arrestin and deubiquitinase targeting.

Near-atomic structures of the BBSome reveal a novel mechanism for transition zone crossing

The paper reveals how the BBSome facilitates GPCR transport across the transition zone by extracting amphipathic helices from the inner leaflet of the membrane.

BBSome trains remove activated GPCRs from cilia by enabling passage through the transition zone

The paper shows that BBSome trains transport activated GPCRs across the transition zone, but exit from cilia is hindered by a second diffusion barrier.